Structural and dynamic insights into the energetics of activation loop rearrangement in fgfr1 kinase

HIGHLIGHTS

• who: Tobias Klein from the for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds , JT, UK* These authors contributed equally to this work. have published the Article: Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 23/07/2015
• how: Despite concerted efforts to develop type II inhibitors of FGFR1 kinase in the own drug discovery programme the authors obtained only type I inhibitors as confirmed by X-ray crystallographic analysis of 470 compounds and none of the 430 . . .
  

   

  

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