Structural and functional analysis of human pannexin 2 channel

HIGHLIGHTS

  • who: Zhihui He from the (UNIVERSITY) have published the paper: Structural and functional analysis of human pannexin 2 channel, in the Journal: (JOURNAL) of 16/03/2023
  • what: The authors show that PANX2 displays a similar anion permeability sequence as VRAC, and that PANX2 channel activity is inhibited by a commonly used VRAC inhibitor, DCPIB.
  • how: Singleparticle cryo-EM data were collected with a dose of ~5.23 electrons per u00c52 per second and each movie was recorded with a 9.36 s exposure with 46 total frames (representing an accumulated dose of . . .

     

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