Structural and functional basis of the serine protease-like hepatocyte growth factor ù²-chain in met binding and signaling*

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• who: Daniel Kirchhofer from the (UNIVERSITY) have published the article: Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor Ù²-Chain in Met Binding and Signaling*, in the Journal: (JOURNAL) of April/29,/2004
• what: Based on the structural similarity of HGF with chymotrypsin-like serine proteases and plasminogen in particular, the authors propose that this activation process is associated with structural changes occurring in the HGF ␤-chain. The authors provide evidence that the "activated" form of the HGF ␤-chain contains a distinct Met binding_site located in a region that corresponds to the . . .
  

   

  

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