Structural and functional characterization of the human thymidylate synthase (hts) interface variant r175c, new perspectives for the development of hts inhibitors

HIGHLIGHTS

• who: Cecilia Pozzi et al. from the Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence, University of Siena, via Aldo Moro, Siena, Italy have published the paper: Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors, in the Journal: (JOURNAL)
• what: The authors report the generation and the functional and structural characterization of a new hTS interface variant in which Arg175 is replaced by a cysteine. The authors report on the generation, expression, andresidue characterization the enzyme function and dimerization .
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