Structural and mechanistic implications of metal binding in the small heat-shock protein αb-crystallin*

HIGHLIGHTS

• who: Andi Mainz from the TD. Goddard and D. G. Kneller, University of California, San Francisco, CA. have published the research work: Structural and Mechanistic Implications of Metal Binding in the Small Heat-shock Protein αB-crystallin*, in the Journal: (JOURNAL) of September/29,/2011
• what: By using solution- and MAS solid-state NMR spectroscopy, the authors demonstrate here how Cu(II) interacts with ␣B. Cu(II)-induced broadening of the oligomeric ensemble of ␣B is accompanied by enhanced chaperone activity. The authors propose a model in which Cu(II) affects dynamics of the dimeric . . .
  

   

  

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