Structural basis for activation of dnmt1

HIGHLIGHTS

• who: Amika Kikuchi from the Cryo-EM data collection A , u00b5L of the protein solutions was applied onto the glow-discharged holey carbon grids (Quantifoil Cu, /1.3, mesh). The grids were plunge-frozen in liquid ethane using a Vitrobot Mark IV (Thermo Fisher Scientific). Parameters for plunge-freezing were set as follows: blotting time, s have published the article: Structural basis for activation of DNMT1, in the Journal: (JOURNAL) of 11/06/2022
• what: The authors report the cryo-EM structure of human DNMT1 bound to its two natural activators: hemimethylated DNA and ubiquitinated . . .
  

   

  

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