Structural basis for ell2 and aff4 activation of hiv-1 proviral transcription

HIGHLIGHTS

• who: Shiqian Qi from the Department of Urology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and National Collaborative Innovation Center, Chengdu have published the article: Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 30/01/2017
• what: The intrinsically disordered scaffold proteins AFF1/4 and the elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 Here the authors report the 2.0-u00c5 resolution crystal structure of the human ELL2 C-terminal domain . . .
  

   

  

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