HIGHLIGHTS
- who: Youxin Kong from the Division University of Oxford, Oxford, United Kingdom have published the Article: Structural Basis for Plexin Activation and Regulation, in the Journal: (JOURNAL)
- what: Based on these results, the authors propose that, before signaling, PlxnAs exist as pre-formed dimers in which the association between the ring-like PlxnA ectodomains maintains a separation of their cytoplasmic domains. The structural, microscopy, and functional data on full-length PlxnA ectodomains the authors report here show that PlxnA ectodomains are autoinhibited through intermolecular cis-interaction prior to ligand binding and support the notion of . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.