Structural basis for pore blockade of human voltage-gated calcium channel cav1.3 by motion sickness drug cinnarizine

HIGHLIGHTS

• who: Xia Yao from the (UNIVERSITY) have published the research: Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine, in the Journal: (JOURNAL) of 11/02/2022

SUMMARY

Received Published online: 27 April 2022 structure of Cav1.3 treated with cp-PYT as the apo state (Supplementary information, Figs S2-S4 and Table S1). Similar to rabbit Cav1.1, the conformation of human Cav1.3 is consistent with an inactivated state, as all voltage-sensing domains (VSDs) are depolarized and the intracellular gate of . . .

 



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