HIGHLIGHTS
- who: Christian Grethe from the (UNIVERSITY) have published the research: Structural basis for specific inhibition of the deubiquitinase UCHL1, in the Journal: (JOURNAL) of 29/04/2022
- what: The authors report the potent and non-toxic chemogenomic pair of activity-based probes GK13S and GK16S for UCHL1. The authors focused on compound GK13S, which showed the strongest DUB-probe competitive signal in lysate, and synthesized a systematic set of compounds comprising probes of both stereoisomers (GK13S and GK13R), minimal probes lacking the central aromatic specificity element (GK16S and GK16R) as well as inactive controls lacking . . .
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