Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core

HIGHLIGHTS

• who: Guilherme A. P. de Oliveira from the Institut Universidade für Molekulare Pharmakologie, Berlin, Germany have published the article: Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core, in the Journal: Scientific Reports Scientific Reports
• what: The authors provide molecular evidence of how hydrophobic_interaction and the formation of water-excluded cavities jointly contribute to the assembly and stabilization of the fibrils. The authors demonstrate that the major ensemble of species released from HHP-disturbed fibrils are monomers that present a different dynamic behavior at the NAC and . . .
  

   

  

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