Structural basis for the dual catalytic activity of the legionella pneumophila ovarian tumor (otu) domain deubiquitinase lota

HIGHLIGHTS

• who: Jiwei Luo from the (UNIVERSITY) have published the Article: Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA, in the Journal: (JOURNAL) of August/12,/2022
• what: This study provides insights into the mechanism underlying the dual catalytic activity of the OTU DUB LotA. The authors determined the structure of LotA1-542 with Ub and uncovered the unique DUB from the obligate intracellular pathogen L pneumophila that is capable of specifically cleaving K6-linked diUb and polyUb chains relying on two OTU DUB domains. The experiment . . .
  

   

  

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