Structural basis for the inhibition of coronaviral main proteases by a benzothiazole-based inhibitor

HIGHLIGHTS

• who: Xiaohui Hu and colleagues from the School of Basic Medical Sciences, Nanchang University, Nanchang, China have published the Article: Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor, in the Journal: Viruses 2022, 2075 of /2022/
• what: The authors investigated the molecular basis for YH-53 inhibiting Mpro using a structure-based approach.
• how: This study supports that YH-53 can be used as a novel scaffold and provides critical information for the optimization and design of more potent inhibitors against SARS-CoV-2. The results showed . . .
  

   

  

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