Structural basis for the inhibition of iapp fibril formation by the co-chaperonin prefoldin

HIGHLIGHTS

• who: Ricarda Tu00f6rner from the University de Biologie Structurale (IBS), des Martyrs, Grenoble, France have published the Article: Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report the mechanistic study of IAPP fibrillation inhibition by the HSP60 type II co-chaperonin prefoldin (PFD). The authors show that inhibition of elongation and secondary nucleation is achieved by the interaction of PFD with IAPP fibril ends and surface, which subsequently leads to lower fibrillation rates and to the formation of clustered . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.