Structural basis for the simultaneous recognition of nemo and acceptor ubiquitin by the hoip nzf1 domain

HIGHLIGHTS

• who: Simin Rahighi from the Chapman University have published the Article: Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain, in the Journal: Scientific Reports Scientific Reports
• what: By consolidating the information obtained from the previously reported crystal_structures of HOIP catalytic domains and the current crystal_structure containing the NZF1, NEMO substrate, and ubiquitin, the authors propose a model for the site-specific linear ubiquitination of NEMO by HOIP (Fig 3C).

SUMMARY

The NZF1-binding_site is distinct and separated from the UBAN domain by ~ 25 . . .

 



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