HIGHLIGHTS
- who: Jiale Liang from the (UNIVERSITY) have published the article: Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation, in the Journal: (JOURNAL)
- how: For individual experiments the authors calculated Span/EC50 of GPR174 mutants relative to that of WT GPR174 a dimensionless parameter known as relative intrinsic activity (RAi)57 and used its log-transformed value (Log RAi) to denote ligand response activity of the mutants. For the N-acylation of LysoPS derivative cpd8a docking the authors used the cryo-EM structure of active GPR174 as the start model the receptor was prepared . . .
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