Structural basis of mutation-dependent p53tetramerization deficiency

HIGHLIGHTS

  • who: Marta Rigoli and collaborators from the Current address: Sibylla Biotech SRL, Piazzetta Chiavica, Verona, Italy have published the research: Structural Basis of Mutation-Dependent p53Tetramerization Deficiency, in the Journal: (JOURNAL) of 15/07/2022
  • how: The results showed that sim352 within the p53 tetramer for all of the simulated systems. The results showed that ilarly to the WT a charged histidine at position 337 and the double-mutant protein similarly to the WT a charged histidine at position 337 and the double-mutant protein R337D/D352R displayed distance distributions compatible with the formation of . . .

     

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