HIGHLIGHTS
- who: Nisha Pillay from the (UNIVERSITY) have published the research: Structural basis of tankyrase activation by polymerization, in the Journal: (JOURNAL) of 15/Oct/2021
- what: The authors report the cryo-electron microscopy reconstruction of a filament formed by a minimal active unit of tankyrase, comprising the polymerizing sterile alpha motif (SAM) domain and its adjacent catalytic domain. The authors demonstrate that polymerization gives rise to both PARP-PARP head and tail interfaces that collectively promote tankyrase catalysis, polymerization, contribute to both catalytic and non-catalytic functions of tankyrase in WNT-u03b2-catenin signalling and . . .
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