Structural basis of the binding of merlin ferm domain to the e3 ubiquitin ligase substrate adaptor dcaf1*

HIGHLIGHTS

  • who: Youjun Li from the (UNIVERSITY) have published the research work: Structural Basis of the Binding of Merlin FERM Domain to the E3 Ubiquitin Ligase Substrate Adaptor DCAF1*, in the Journal: (JOURNAL) of May/23,/2014
  • what: The authors show that Merlin-FERM directly binds to a short fragment of DCAF1 located at the extreme C-terminal end 14674 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 289.

SUMMARY

    Recent investigation indicated that Merlin is also involved in a distinct cell growth regulation mechanism by accumulating in nucleus and inhibiting the activity of nuclear . . .

     

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