Structural basis of vitamin c recognition and transport by mammalian svct1 transporter

HIGHLIGHTS

• who: Mingxing Wang from the (UNIVERSITY) have published the research: Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter, in the Journal: (JOURNAL) of 28/02/2023
• future: Future work needs to determine SVCT structures in outward-facing and occluded states to pinpoint the detailed conformational changes during a transport cycle for this family of vitamin C transporters.

SUMMARY

Vitamin_C binds at the core domain of each subunit, and two potential sodium ions are identified near the binding_site. Lipid binding was previously shown to be important for UapA . . .

 



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