Structural characterization of human heat shock protein 90 n-terminal domain and its variants k112r and k112a in complex with a potent 1,2,3-triazole-based inhibitor

HIGHLIGHTS

• who: Giusy Tassone and colleagues from the Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence, University of Siena, Via Aldo Moro, Siena, Italy have published the article: Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor, in the Journal: (JOURNAL)
• what: Abolishing the contribution provided by these residues does not alter the binding mode of the natural nucleotide substrate, as verified in the earlier studies by the mutation to alanine of this position (K112A variant . . .
  

   

  

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