Structural characterization of the icos/icos-l immune complex reveals high molecular mimicry by therapeutic antibodies

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• who: Edurne Rujas from the Children Research Institute, Toronto, ON M G , CanadaUniversity of have published the Article: Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report the crystal_structure of the co-complex between human ICOS and its ligand ICOS-L at 3.3 Å resolution, which reveals the molecular details of immune receptor 2 specificity. In the absence of functional data supporting this dimeric interface, the authors propose that the antiparallel ICOS dimer arrangement observed in the . . .
  

   

  

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