Structural comparison of homologous protein-rna interfaces reveals widespread overall conservation contrasted with versatility in polar contacts

HIGHLIGHTS

• What: The study has important implications for predicting protein-RNA interactions both by providing useful rules for transferring contacts from a template with known structure to an interface of interest and by paving the way for applying machine-learning techniques to integrate these patterns of contact conservation. This study showed that above a sequence identity threshold of 30-35%, structural binding modes are similar and that many structurally similar complexes display low sequence identity. The authors focused on the analysis of protein-RNA interface evolution, aiming to unravel the sequence and structural properties connected with interface conservation . . .
  

   

  

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