Structural dissection reveals a general mechanistic principle for group ii chitinase (chtii) inhibition

HIGHLIGHTS

  • who: Wei Chen from the (UNIVERSITY) have published the research work: Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition, in the Journal: (JOURNAL) of April/30,/2019
  • what: The authors report the structural characteristics of four molecules that exhibited similar levels of inhibitory activity against OfChtII, a group II chitinase from the agricultural pest Asian corn borer Ostrinia furnacalis. The results of this study provide insights into a general mechanistic principle that confers inhibitory activity against ChtII, which could facilitate rational design of agrochemicals that target ecdysis of insect pests . . .

     

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