Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-iiia

HIGHLIGHTS

  • who: Michau0142 Zieliu0144ski and colleagues from the Department of Biochemistry, McGill University, Montru00e9al, Quu00e9bec, Canada, Centre de Recherche en have published the research work: Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa, in the Journal: PLOS ONE of 28/01/2022
  • what: AAC(3)-IIIa and its fellow isozymes utilize both 4,5- and 4,6-disubstituted aminoglycosides providing this enzyme with the broadest substrate specificities of any AAC(7).

SUMMARY

    The authors outline the structural and kinetic basis of isoA`s ability to utilize its tripartite active_site to render . . .

     

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