Structural, enzymatic and spatiotemporal regulation of pp2a-b55 phosphatase in the control of mitosis

HIGHLIGHTS

  • who: PP and collaborators from the Brunel University London, United Kingdom have published the paper: Structural, enzymatic and spatiotemporal regulation of PP2A-B55 phosphatase in the control of mitosis, in the Journal: (JOURNAL)
  • what: The current model proposes that, at the G2/M transition, the colocalization of Gwl with Cyclin B/Cdk1 in the nucleus, away from PP2A-B55, will permit their activation.

SUMMARY

    Cyclin B degradation triggers a specific and progressive program of protein dephosphorylation that will establish the correct temporal pattern of events required for the reformation of a . . .

     

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