Structural features discriminating hybrid histidine kinase rec domains from response regulator homologs

HIGHLIGHTS

• who: Mitchell Bru00fcderlin from the (UNIVERSITY) have published the research: Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs, in the Journal: (JOURNAL)

SUMMARY

Strikingly, all active_site residues of the canonical Rec-fold are pre-arranged for phosphoryl-binding and BeF3- binding does not alter secondary or quaternary_structure, indicating the absence of allosteric changes, the hallmark of RRs. To test for distinguishing features of Recinter domains, the authors analyze the structure and dynamics of the C-terminal Rec domain of the well-studied HHK CckA (CckARec) and find, quite unusual . . .

 



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