Structural framework for covalent inhibition of clostridium botulinum neurotoxin a by targeting cys165*

HIGHLIGHTS

• who: Enrico A. Stura from the (UNIVERSITY) have published the Article: Structural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165*, in the Journal: (JOURNAL) of September/28,/2012
• what: This study reveals that in catBoNT/A Cys165 is not playing a key structural role but contributes to in enzyme activity. Instead of increasing the size of the noncovalent inhibitors to further optimize interactions with enzyme active_site, this study reveals on a structural basis how small covalent inhibitors of catBoNT/A can be developed.
• how: The experiments were carried out . . .
  

   

  

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