Structural insights into a shared mechanism of human sting activation by a potent agonist and an autoimmune disease-associated mutation

HIGHLIGHTS

• who: Zuoquan Xie from the (UNIVERSITY) have published the article: Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, in the Journal: (JOURNAL)
• what: The authors designed a new diABZI-based STING agonist HB3089 that triggers substantial antitumor immunity and exhibits robust anti-tumor activity. The authors took an approach of rational design based on diABZI compounds and obtained a more asymmetric diABZI structure, HB3089. The study provides useful structural information for the rational design of therapies for treating cancers or autoimmune disorders, through . . .
  

   

  

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