HIGHLIGHTS
- who: Sreekanth Rajan from the Darmstadt University of Technology, Germany have published the Article: Structural insights into Plasmodium PPIases, in the Journal: (JOURNAL)
- what: To support this, the estimated lower physiological levels of PfFKBP35 (0.05-0.1mM) in the parasite in comparison to hsFKBP12 (3-5mM) (Braun et_al, 2003) also aid in achieving this, provided the authors design nonimmunosuppressive inhibitors with higher affinity towards Cys106 and Ser109. The studies showed that this molecular interaction is negligible in the absence of FK506, which was enhanced when FK506 was added (Yoon et_al, 2007).
- how . . .
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