who: Hang Li from the (UNIVERSITY) have published the paper: Structural insights into selective inhibition of leishmanial GDP-mannose pyrophosphorylase, in the Journal: (JOURNAL)
what: Although the reason that various GDP-MPs adopt distinct oligomeric forms is far from obvious, the authors propose here the extra controls that enable the assembling of supramolecular eukaryotic GDP-MPs with extra interprotomer contacts offer a more robust avenue for activity modulation, presumably to better meet the ever-changing metabolic needs that are often faced by eukaryotes.
how: The mechanisms proposed above have been validated by mutagenesis . . .
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