Structural insights into the high selectivity of the anti-diabetic drug mitiglinide

HIGHLIGHTS

  • who: Tian-Le Xu and collaborators from the Shanghai Jiao Tong University, China have published the research work: Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide, in the Journal: (JOURNAL)
  • how: The authors made a truncated Mesocricetus auratus SUR1 construct maSUR1core (from 208 to C terminal) based on the previous work by Ding et_al .

SUMMARY

    More than 400 million people are living with diabetes worldwide, and type 2 diabetes (T2DM) accounts for nearly 90% of patients with diabetes (Chatterjee et_al, 2017). KATP channels can sense intracellular ATP . . .

     

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