HIGHLIGHTS
- who: Yang Yang from the (UNIVERSITY) have published the research work: Structural insights into the human niacin receptor HCA2-Gi signalling complex, in the Journal: (JOURNAL) of 21/09/2022
- what: The authors report the cryo-electron microscopy structure of the HCA2-Gi signalling complex with the potent agonist MK-6892, along with crystal_structures of HCA2 in inactive state.
- how: The mutagenesis data showed that H13334.51E mutation decreased the Gi activity of both MK-6892 and niacin but H13334.51F retains the activities of MK-6892 (Fig 3f) and niacin (Supplementary Fig . . .
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