HIGHLIGHTS
- who: Babatunde Ekundayo from the (UNIVERSITY) have published the Article: Structural insights into the regulation of Cas7-11 by TPR-CHAT, in the Journal: (JOURNAL) of 27/04/2022
- what: The authors show that DmTPR-CHAT stabilizes crRNA-bound DmCas7-11 in a closed conformation via a network of interactions mediated by the DmTPR-CHAT N-terminal domain, the DmCas7-11 insertion finger and Cas11-like domain, resulting in reduced target RNA accessibility and cleavage. Based on the structural and biochemical analyses, the authors propose a model of Cas7-11 regulation by TPR-CHAT via . . .
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