HIGHLIGHTS
- who: Di Yu from the (UNIVERSITY) have published the research: Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma, in the Journal: (JOURNAL) of 28/06/2022
- what: The authors report that BRD4-NUT contains two transactivation domains (TADs) in NUT that bind to the TAZ2 domain in p300. The study provides a previously underappreciated structural mechanism illuminating BRD4-NUT`s bipartite p300 recruitment and activation in NUT carcinoma that nucleates a feed-forward loop for propagating histone hyperacetylation and chromatin condensation to sustain aberrant . . .
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