HIGHLIGHTS
- who: Ivan V. Chernikov and colleagues from the Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences have published the paper: Structural Modifications of siRNA Improve Its Performance In Vivo, in the Journal: (JOURNAL)
- what: The described approaches for increasing the molecular weight of siRNA make it possible to increase the circulation time of siRNA in the blood and, consequently, biodistribution.
- how: An alternative approach was proposed where circular duplexes were used obtained either by enzymatic cyclization of strands containing a photo-cleavable linker in the middle . . .
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