HIGHLIGHTS
- who: Edward Spink and colleagues from the of Chemistry and, University of Notre Dame, Notre Dame, Indiana have published the paper: Structure-Activity Relationship for the Oxadiazole Class of Antibiotics, in the Journal: (JOURNAL)
- what: This model has shown excellent correlation between the minimal-inhibitory concentration (MIC) and ED50 (the effective dose that rescues 50% of the animals from the infection) for 14 u03b2-lactam antibiotics16 and for linezolid . The focus of this SAR study is the variation of structure within ring A of the oxadiazole lead. The authors expressly explored the activity against S . . .
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