Structure activity relationship studies around db18, a potent and selective inhibitor of clk kinases

HIGHLIGHTS

• who: Dabbugoddu Brahmaiah et al. from the Chemveda Life Sciences India PvtLtd, #B-11/1, IDA Uppal, Hyderabad-500039, Telangana, India Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana, India have published the paper: Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases, in the Journal: Molecules 2022, 6149 of 29/05/2022
• what: Guided by docking experiments the authors focused on the less constrained part of the scaffold and showed that drastically different substituents can be tolerated here. All molecules prepared during this study have been first screened against . . .
  

   

  

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