Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production

HIGHLIGHTS

• What: This study provides the structural basis for the substrate selectivity and catalytic activity of CsAlaDC and AtSerDC and sheds light on a new direction for the efficient industrial synthesis of theanine. eLife assessment This study reports comparative biochemical and structural analysis of two PLP decarboxylase enzymes from plants. The authors attempt to understand the mechanism of functional divergence of plant AlaDC and SerDC by analyzing their structural characteristics. The investigation has revealed the presence of a distinctive zinc_finger structure (as depicted in Figure 3A and 3D ) located at the C-terminus of CsAlaDC and AtSerDC. The . . .
  

   

  

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