Structure and function of the toscana virus cap-snatching endonuclease

HIGHLIGHTS

  • who: Rhian Jones and colleagues from the Aix-Marseille Université, CNRS, AFMB UMR, Marseille, France, INSERM, AFMB UMR7257, Marseille, France, Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Hamburg, Germany and , Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany have published the Article: Structure and function of the Toscana virus cap-snatching endonuclease, in the Journal: (JOURNAL)
  • what: The authors report TOSV endonuclease crystal_structures in the apo form, in complex with a di-ketoacid inhibitor (DPBA) and in an intermediate state of inhibitor release, showing details on substrate binding and active_site . . .

     

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