Structure and neutralization mechanism of a human antibody targeting a complex epitope on zika virus

HIGHLIGHTS

  • who: Cameron Adams et al. from the Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill have published the research work: Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus, in the Journal: (JOURNAL) of January/10,/2023
  • what: The authors propose that beyond antibody binding strength the ability of human antibodies to cross-link E-proteins is a critical determinant of flavivirus neutralization potency. To better define the structural basis and mechanism of ZIKV neutralization by human antibodies, here the authors focused on . . .

     

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