Structure-based design of 2-aminopurine derivatives as cdk2 inhibitors for triple-negative breast cancer

HIGHLIGHTS

• who: -Aminopurine Derivatives as CDK et al. from the Shandong University, Ji`nan, China, Shandong Hospital and Institute, Shandong First Medical University, Jinan, China have published the article: Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer, in the Journal: (JOURNAL)
• what: The authors further investigated the antitumor activity of three compounds using MDA-MB-231 cells, which were derived from TNBC patients. The authors designed a series of 2-aminopurine derivatives as new CDK2 inhibitors based on the fragmentcentric pocket mapping of crystal_structure.
• how: When the . . .
  

   

  

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