Structure-based inhibitor design for an enzyme that binds different steroids

HIGHLIGHTS

• who: Wei Qiu from the Wei Qiu1, Ming Zhou, Mausumi Mazumdar1, Arezki Azzi, Dalila Ghanmi, Van Luu-The, Fernand Labrie, and Sheng-Xiang Lin, From the Canadian Institutes of Health Research Group in Molecular Endocrinology, Laval University Medical Center, Centre Hospitalier de Universités de Québec and Laval University, Quebec G V , Canada Human type , ␤-hydroxysteroid dehydrogenase plays a crucial role in local androgen formation in prostate tissueSeveral chemicals were synthesized and tested for their ability to inhibit this enzyme, and a series of estradiol derivatives bearing a lactone on the, ring were found to inhibit . . .
  

   

  

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