HIGHLIGHTS
- who: Brian E. Hall from the (UNIVERSITY) have published the paper: Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange*, in the Journal: (JOURNAL) of February/23,/2001
- what: The authors have investigated the interaction of Ras with its GEF Sos using structure-guided mutagenesis.
- how: The authors have utilized the information derived from the crystal_structure to test specific predictions concerning the functional interactions between Ras and Sos.
SUMMARY
Mammalian cells contain two sos genes, sos1 and sos2, encoding . . .
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