Structure-function analysis of human tyw2 enzyme required for the biosynthesis of a highly modified wybutosine (yw) base in phenylalanine-trna

HIGHLIGHTS

• who: Virginia Rodriguez and colleagues from the Cellular Biology, Georgetown University Medical Center, Washington, District of Columbia, United States of America, Department of Chemistry and Biotechnology have published the Article: Structure-Function Analysis of Human TYW2 Enzyme Required for the Biosynthesis of a Highly Modified Wybutosine (yW) Base in Phenylalanine-tRNA, in the Journal: (JOURNAL) of June/28,/2012
• what: Using complementation of a DTYW2 strain the authors demonstrate here that human TYW2 (hTYW2) is active in yeast and can synthesize the yW of yeast tRNAPhe.

SUMMARY

Though over 100 modified . . .

 



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