Structure-function analysis of the thap zinc finger of thap1, a large c2ch dna-binding module linked to rb/e2f pathways*

HIGHLIGHTS

• who: Damien Bessie̠re from the (UNIVERSITY) have published the article: Structure-Function Analysis of the THAP Zinc Finger of THAP1, a Large C2CH DNA-binding Module Linked to Rb/E2F Pathways*, in the Journal: (JOURNAL) of February/15,/2008
• what: The authors report here the three-dimensional structure and structure-function analysis of the sequence-specific DNA-binding THAP zinc_finger of human THAP1, the prototype of a novel family of cellular factors involved in pRb/E2F cell cycle pathways. The authors identified five additional residues that are essential for DNA binding activity.
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