Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

HIGHLIGHTS

• who: Xin Li from the (UNIVERSITY) have published the Article: Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins, in the Journal: (JOURNAL)
• what: This review is focused on MLL1, since it is the most studied and involved in a number of chromosomal translocations causing 5-10% acute leukemia in children and adults with a poor prognosis .
• future: Investigation using MLL1AF4 and AFF4 with deletion of various AF4/AFF4 domains showed that only the CHD domain of AFF4/ AF4 is required for leukemic transformation . . .
  

   

  

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