Structure-guided design of a potent clostridiodes difficile toxin a inhibitor

HIGHLIGHTS

• who: ufeffGregufeff ufeffHussackufeff from the Lund University, United States have published the research: Structure-guided design of a potent ufeffClostridiodes difficileufeff toxin A inhibitor, in the Journal: (JOURNAL)
• what: This study provides a dramatic example of how high-resolution crystal_structures can be used to tailor the design of a multivalent toxin-inhibiting protein to match the molecular geometry of a toxin to generate novel and potent therapeutics. The authors used the crystal_structures of VHHs A20 and A26 in complex with C. difficle TcdA that the authors had previously determined to guide the design of a . . .
  

   

  

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