HIGHLIGHTS
- who: Fabiana Renzi from the (UNIVERSITY) have published the paper: Structure of γ-Secretase and Its Trimeric Pre-activation Intermediate by Single-particle Electron Microscopy*, in the Journal: (JOURNAL) of June/17,/2011
- how: For three-dimensional reconstruction the authors employed a procedure comparable to the one described for mature ␥-secretase.
SUMMARY
The neuropathological hallmarks of Alzheimer disease include the presence of senile plaques and neurofibrillary tangles throughout the cerebral cortex and hippocampus and the loss of neurons in these specific brain areas. This intramembrane proteolytic activity of ␥-secretase is critical in . . .
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