Structure of a dominant negative mutant reveals a stalled intermediate state of anthrax protective antigen pore maturation

HIGHLIGHTS

• who: Harry Scott and colleagues from the Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA have published the article: Structure of a dominant negative mutant reveals a stalled intermediate state of anthrax protective antigen pore maturation, in the Preprint: biorxiv of 15/06/2020
• what: The authors show that the dominant negative D425A mutation stalls the formation of the pore at a reversible intermediate maturation state which exhibits many of the structural aspects of the pore but fails to form the phi(u0278)-clamp and beta-barrel structure needed for full pore maturation . . .
  

   

  

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